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الثلاثاء، 29 مارس 2011

what is arthritis

Arthritis is the swelling of one or more joints in the body. It may affect the knees, wrists or a some part of the spinal column. Rheumatoid arthritis and osteoarthritis are the two main types of arthritis. The other types are septic arthritis, gout, pseudogout, juvenile idiopathic arthritis, still’s disease and ankylosing spondylitis. Some types of arthritis may be caused secondary to some diseases like lupus erhythematosus, psoriatic arthritis, reactive arthritis, hemochromatosis, Henoch-Schonlein purpura, lime disease and many others. Some diseases are like arthritis like hypertrophic osteoarthropathy, osteoporosis, fifth disease (parvovirus infection) and multiple myeloma.
The revised criteria for the classification of rheumatoid arthritis (RA) were formulated from a computerized analysis of 262 contemporary, consecutively studied patients with RA and 262 control subjects with rheumatic diseases other than RA (non-RA). The new criteria are as follows: 1) morning stiffness in and around joints lasting at least 1 hour before maximal improvement; 2) soft tissue swelling (arthritis) of 3 or more joint areas observed by a physician; 3) swelling (arthritis) of the proximal interphalangeal, metacarpophalangeal, or wrist joints; 4) symmetric swelling (arthritis); 5) rheumatoid nodules; 6) the presence of rheumatoid factor; and 7) radiographic erosions and/or periarticular osteopenia in hand and/or wrist joints. Criteria 1 through 4 must have been present for at least 6 weeks. Rheumatoid arthritis is defined by the presence of 4 or more criteria, and no further qualifications (classic, definite, or probable) or list of exclusions are required. In addition, a “classification tree” schema is presented which performs equally as well as the traditional (4 of 7) format. The new criteria demonstrated 91–94% sensitivity and 89% specificity for RA when compared with non-RA rheumatic disease control subjects.

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